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Experts develop a list of competencies in antimicrobial prescribing and stewardship

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 12 2018Experts from across Europe have developed a set of competencies in antimicrobial prescribing and stewardship, using a structured consensus procedure. This ESCMID-led study has resulted in a list of competencies that represent the minimum standards that all independent prescribers of antimicrobials should reach to practice according to principles of responsible antibiotic use. The list of competencies is highly relevant for educators, regulators and professional bodies throughout Europe, as well as for individual prescribers.The competencies set comprises 35 competency points divided into three sections: Core concepts in microbiology, pathogenesis and diagnosing infections; Antimicrobial prescribing; and Antimicrobial stewardship.Related StoriesStudy: Surveillance for antibiotic-resistant bacteria continues to be core focus for healthcare facilitiesFinger-prick blood test could help prevent unnecessary antibiotic prescribing for patients with COPDInterdisciplinary approach reduces the use of broad spectrum antibiotics”Despite widespread agreement that we need to use antibiotics responsibly, until now, there has been no consensus on what the minimum standards for responsible use are according to which prescribers in Europe should practice”, explains Dr. Oliver Dyar, a researcher in public health at Karolinska Institutet, Stockholm, Sweden, who led the study and is treasurer of the ESCMID Study Group for Antimicrobial StewardshiP (ESGAP).”We hope that this work will help guide those who train doctors, nurses and pharmacists to prescribe antibiotics, and at the same time support the regulators and professional societies that are responsible for setting and maintaining standards” Dr Oliver Dyar said, adding “These competencies could play an important role in harmonizing approaches in antimicrobial stewardship in Europe. We also believe that most of the competencies are relevant for prescribers in other contexts, and it is essential that on a global basis we invest in ways to improve on how we use antibiotics.”The study used a RAND-modified Delphi consensus procedure and involved 65 experts from 24 European countries, most of whom were infectious diseases specialists, clinical microbiologists, or pharmacists. This expert panel reviewed a draft set of competencies which was originally developed by a multidisciplinary panel in the UK, and had since been adapted to the broader European context through consultation with ESCMID Study Groups. Each competency point was assessed for relevance for all independent prescribers in Europe, and the expert panel was able to suggest additional competencies. After three assessment rounds and a face-to-face meeting, there was very high agreement (98%) with the final competencies set.Over the coming years ESCMID and ESGAP will support efforts to implement these ESCMID generic competencies in antimicrobial prescribing and stewardship. Source:https://www.escmid.org/fileadmin/src/media/PDFs/2News_Discussions/Press_activities/2018/Dyar_Press_release_09NOV2018.pdflast_img read more

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Diets containing GM maize have no harmful effects on health or metabolism

Reviewed by James Ives, M.Psych. (Editor)Dec 14 2018For six months, rats were fed a diet containing either GM maize (MON 810 or NK603) or non-GM maize, in varying concentrations. The researchers, using high-throughput biology techniques, did not identify any significant biological markers related to the transgenic maize diet. Neither did anatomic pathology examination reveal any alteration of the liver, kidneys or reproductive system of the rats fed diets containing these GMOs. This research, published on December 10, 2018 in Toxicological Sciences, does not reveal any harmful effects related to the consumption of these two types of GM maize in the rat even after lengthy periods of exposure.The researchers used two well-known types of GM maize: MON 810, which produces the protein Bt rendering it resistant to certain insects, and NK603 in which the modification of a gene renders it resistant to glyphosate. For 6 months, the rats were fed a diet containing either transgenic maize or non-GM control maize. This time period, which is double that of the test required by European regulations, is equivalent to one third of the average lifespan of rats.The objective of the researchers was to test for early biomarkers of biological function alterations in rats fed GM maize over periods of 3 and 6 months. For that, they used two ultra-sensitive high-throughput techniques: transcriptomics (gene expression) and metabolomics (study of the compounds derived from the body’s functioning). These techniques were used to identify and measure metabolites (amino acids, sugars and other small molecules) and to characterize the expression of messenger RNA and cellular microRNA. These methods are capable of detecting a broad spectrum of metabolic variations. The researchers identified markers able to differentiate the MON810 and NK603 diets. However, following the six-month period of the experiment, no significant differences were identified between the GM and non-GM diets, from the biological point of view.In addition, in the rats fed the GM diets, anatomic pathology techniques (macro- and microscopic study of the tissues to detect potential abnormalities) revealed no alteration of the organs, particularly the liver, kidneys and reproductive system.As such, the researchers did not detect any harmful effects of the MON810 and NK603 maize diets on the health and metabolism of the rodents, even after a lengthy exposure period.Related StoriesNew therapy shows promise in preventing brain damage after traumatic brain injuryALS mobility and survival could be improved by increasing glucoseHighlights and key takeaways from the 2019 Boston Bacterial Meeting (BBM)1 The GMO 90+ project In 2010, the French Ministry of Ecology launched the Risk’OGM program, in the context of the 2008 law on genetically modified organisms for the establishment of a new legal and regulatory framework based notably on the principle of a triple evaluation of the impact of GMOs – from the health, environmental and socioeconomic standpoints. To set this dynamic in motion and fulfil public authority requirements in terms of expertise, guidance and completed research on GMOs, two calls for research proposals were held, in 2010 and 2013, respectively. The GMO 90+ project was selected during the 2013 call for proposals, with the following scope: to test for biomarkers predictive of biological effects in the study of the subchronic toxicity (3 and 6 months) of GMOs in the rat. Driven by a consortium pooling the various scientific competences, the purpose of this research was to determine whether the feeding of rats with genetically-modified maize led to metabolic changes which could be linked to early effect biomarkers (measurable biological characteristic). The objective was to provide key data which could be used in risk evaluation processes. http://recherche-riskogm.fr/fr/page/gmo90plus2 List of project partners: 1-Toxalim (Research Centre in Food Toxicology), Université de Toulouse, INRA, ENVT, INP-Purpan, UPS, Toulouse, France. 2-INSERM UMR-S1124, Toxicologie Pharmacologie et Signalisation cellulaire, Université Paris Descartes, USPC, Paris, France 3- Centre de Recherche sur l’Inflammation (CRI), INSERM UMRS 1149, Paris, France. 4- Laberca, ONIRIS, UMR INRA 1329, Nantes, France 5- Université de Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) – UMR_S 1085, Rennes, France. 6- Methodomics, France. 7- Institut de Mathématiques de Toulouse, UMR5219 – Université de Toulouse, CNRS – UPS IMT, Toulouse, France. 8- Anses, Maisons-Alfort, France. 9- Profilomic, Saclay/Gif sur Yvette, France 10- UMR1332 Biologie du Fruit et Pathologie, INRA, Université de Bordeaux, Villenave d’Ornon, France. 11- UR 1264, MycSA, INRA, Villenave d’Ornon, France. 12- Laboratoire Reproduction et Développement des Plantes, University Lyon, ENS de Lyon, UCB Lyon 1, CNRS, INRA, Lyon, France 13- CRO CitoxLAB, Evreux.Source: https://presse.inserm.fr/en/mon-810-and-nk603-gm-maize-no-effects-detected-on-rat-health-or-metabolism/33249/ read more

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Bedfont named as Technology category finalist for 2019 National Family Business Awards

first_imgMay 31 2019Medical device manufacturer, Bedfont Scientific Ltd., reaches the Family Business Awards finals for the Technology category. Created in order for family-owned businesses to be recognized and celebrated for their extraordinary contribution to the economy, the National Family Business Awards chose local med-tech firm, Bedfont, as a Technology category finalist for the 2019 awards.Established in 1976, Bedfont specializes in the design and manufacture of innovative breath analysis medical devices. Its breath analyzers include carbon monoxide (CO) monitors such as the Smokerlyzer®, used for smoking cessation, and the ToxCO®, used by emergency services, to screen for CO poisoning. The NObreath® FeNO monitor provides accurate analysis of airway inflammation for the control of asthma, and the Gastrolyzer® range aids in the detection of gastrointestinal disorders and food intolerances. Quick and non-invasive, breath analysis is the new blood test.Amalia Brightley-Gillott, Managing Director of Family Business Place, who hosts the awards, says: Jason Smith, Managing Director, comments: Becoming a 2nd generation family business has reinforced our family values and enabled us to create a strong sense of identity and culture for the business as the Bedfont Family. Strong family values can prove instrumental in stabilizing the structure and dynamics within the business resulting in high employee sense of belonging and satisfaction thus increasing productivity, loyalty and profitability. Breath analysis for medical applications is a very niche technology and we are thrilled to be recognized for our contribution to healthcare, by being chosen as a finalist in the Family Business Awards for the Technology category.” Source:Bedfont Scientificcenter_img The winners will be announced at Wembley Stadium on 13th July in what’s set to be a spectacular 10th anniversary celebration of the awards. We’re over the moon to welcome Bedfont Scientific Ltd. as Finalists at this year’s awards. They’re an exceptional example of how family businesses are leading the way, continuing to innovate and thriving in today’s competitive, economically uncertain world.”last_img read more

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Ethanol blending with petrol to double at 8 in current season Oil

first_imgDharmendra Pradhan, Union Petroleum Minister   –  File photo In June, the Centre approved Rs 4,440 crore soft loans for building ethanol production capacity to absorb the excess cane. Petroleum Minister Dharmendra Pradhan said that ethanol blending with petrol is likely to double to 8 per cent in the current season as a better price is being offered by oil marketing companies.The minister also assured additional soft loans to mills for expanding the ethanol capacity.Addressing the 84th annual general meeting of sugar industry body ISMA, he said the government has taken a number of steps in the last four years to bring a “paradigm shift” in the Rs 1 lakh crore sector.“Blending of ethanol with petrol has reached 4 per cent from 1-1.5 per cent in the last four years. In 2018-19 sugar year (October-September), the blending level will reach 7-8 per cent,” Pradhan said.The minister said, “Although buying ethanol is costly for oil marketing companies, because of hike in procurement price, the Centre has taken a holistic view to boost ethanol production for farmers welfare as well as to meet our energy requirements.”Pradhan said the Centre spends Rs 8-10 lakh crore of foreign exchange to meet energy demand by importing crude oil, LNG and other products.He said that the Centre has provided soft loans to the first group of applications for creating ethanol capacity and it is committed to sanctioning loans for the second group. In June, the Centre approved Rs 4,440 crore soft loans for building ethanol production capacity to absorb the excess cane. It will bear interest subvention of Rs 1,332 crore over a period of five years, including moratorium period of one year.According to industry sources, the Centre may provide an interest subsidy of about Rs 1,800 crore in the second round and it may also allow standalone molasses-based distillery to participate in this soft loan programme.Later in September, the Central Government approved an over 25 per cent hike in the price of ethanol produced directly from sugarcane juice for blending in petrol in a bid to cut surplus sugar production and reduce oil imports.The Centre had launched the programme EBP in 2003 on pilot basis which was subsequently extended to 21 states and four Union Territories to promote the use of alternative and environment-friendly fuels.But the target of 10 percent blending of ethanol in petrol was never met. Since 2014, the Central Government notified an administered price for ethanol. The move significantly improved the supply of ethanol during the past four years.The volume of ethanol procured by public sector OMCs has increased from 38 crore litres in ethanol supply year 2013-14 to an estimated 150 crore litres in 2017-18.Earlier, ISMA President Gaurav Goel said the ethanol blending level will reach 8 per cent in 2018-19 as orders for 260 crore litres have been received from OMCs. For 10 per cent blending, there is a requirement of 330 crore litres of ethanol.Goel exuded confidence that blending level would reach 10 per cent by 2020 and 20 per cent by 2022.The ISMA president demanded that the Centre should link sugarcane price to sugar rates as a long term solution for this sector. Goel said there would be no cane arrears and industry would not seek any fund from the Centre if this demand is met. He said the sugar production is likely to fall to 31.5 million tonnes in the current marketing year as against 32.5 million tonnes in the previous year. The annual domestic demand is 26 million tonnes. The opening stock was 10.7 million tonnes as on October 1. Goel said that mills have agreed to export 1 million tonnes of sugar out of 5 million tonnes quota earmarked by the Centre for 2018-19. He recommended a strict action against mills which do not export sugar. COMMENT COMMENTS Published on petroleum December 07, 2018 SHARE SHARE SHARE EMAILlast_img read more

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Karnataka coalition model will be replicated in Delhi RahulKarnataka coalition model will

first_imgMarch 31, 2019 Published on Rahul Gandhi, President, Congress (File photo)   –  PTI SHARE COMMENT national electionscenter_img SHARE SHARE EMAIL Elections 2019 The Congress will demonstrate the functioning of a smooth coalition government in New Delhi while forming the government at the Centre, party President Rahul Gandhi has said.Addressing a Congress-Janata Dal (Secular) [JD(S)] rally on the outskirts of Bengaluru, Rahul said: “ Our formation of a coalition government in Karnataka, and its smooth functioning is an example which we will demonstrate again in Delhi.”Appealing to both, the Congress and the JD(S) workers, Rahul said: “I appeal to both parties’ workers to work harmoniously. Our goal is to defeat the BJP and Prime Minister Narendra Modi.”Talking about farm-loan waivers, Rahul said: “When farmers across the country approached the Central government, Modi and Union Finance Minister Arun Jaitley said it cannot be done. We have no money.”“Karnataka showed the country how it can be done with ease. It generated its own resources. When the Central government failed, it was the State which demonstrated its will. Similarly, governments of Rajasthan, Madhya Pradesh, Chattisgarh are working towards it,” he said.Relief for start-upsBengaluru is called “start-up capital”. Keeping with the spirit of this sector, the Congress President said the party is working out a plan to allow new businesses three years to get permissions and licences. “This is being done to encourage entrepreneurs to create jobs.”Rahul explained that this is being done to remove the draconian and ill-conceived Angel Tax.Earlier, at the rally, JD(S) supremo HD Deve Gowda said: “Since May 23, 2018, we have been workings towards formation of the Mahagathbandhan (Grand Alliance). The BJP has been taunting us that it is not the Mahagathbandhan but maha milawat (adulterated alliance).” “Post-elections, we shall show them the strength of Mahagathbandhan and prove them wrong,” he added. COMMENTSlast_img read more

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